Product Description
Iron Sucrose Description
Iron sucrose is an intravenous iron replacement therapy used to treat iron deficiency anemia, particularly in patients with chronic kidney disease (CKD). It consists of a complex of polynuclear iron (III) hydroxide with sucrose, which helps improve iron absorption and utilization.
Chemical & Physical Properties:
- Chemical Formula: CHFeO (approximate structure)
- Molecular Weight: Varies due to complex nature
- Appearance: Dark brown, aqueous solution for injection
- Solubility: Water-soluble
Mechanism of Action:
Iron sucrose releases bioavailable iron, which binds to transferrin in the bloodstream. Transferrin transports iron to the bone marrow, where it is used for red blood cell (RBC) production, improving hemoglobin levels.
Pharmacokinetics:
- Absorption: Rapidly enters plasma after IV administration
- Distribution: Binds to transferrin and is taken up by the reticuloendothelial system (RES)
- Elimination: Iron is incorporated into hemoglobin or stored as ferritin; excess iron is excreted minimally
Uses & Indications:
- Treatment of iron deficiency anemia in CKD patients
- Patients on dialysis, especially those receiving erythropoietin therapy
- Iron deficiency in patients who cannot tolerate or do not respond to oral iron
Key Details:
- Brand Names: Venofer, among others.
- Administration: Given as an IV infusion or slow IV injection, typically in a healthcare setting.
- Indications:
- Iron deficiency anemia in CKD patients
- Patients undergoing dialysis or erythropoietin therapy
- Cases where oral iron is ineffective or causes side effects
Dosage & Administration:
- Administered based on iron levels and individual needs.
- Typically given in multiple doses over several sessions.
- Requires monitoring to avoid iron overload.
Side Effects:
- Common: Nausea, dizziness, low blood pressure, headaches.
- Serious: Allergic reactions (rare but possible), anaphylaxis, hypotension.
Precautions:
- Should be given under medical supervision.
- Avoid in patients with iron overload disorders like hemochromatosis.
- Monitor hemoglobin and ferritin levels regularly.