Probenecid .

Product Description

We are glad to present ourselves as one of the reputed organization engaged in offering Probenecid. This compound has strong antioxidant properties, able to protect cells from the damage that can occur when chemicals react with oxygen. It is used in drugs help in supporting the immune system and heart health. Probenecid is also used in the treatment of diseases like sickle cell anaemia, idiopathic pulmonary fibrosis and poisoning. This compound is useful to improve respiratory health alleviate liver conditions support certain facets of heart & brain health enhance memory and reduce joint pain.

In addition to being sold under the brand name Probaln, probenecid increases the excretion of uric acid in the urine. Generally, it is used to treat hyperuricemia and gout. It is used to prevent gout and gouty arthritis. An attack of sudden or severe gout will not be treated by this medication, and it may actually worsen it. The drug probenecid is classified as a uricosuric. Taking it lowers high levels of uric acid in your body by assisting your kidneys to eliminate it. Symptoms of gout are caused by crystals forming in the joints when uric acid levels get too high. Your kidneys may also benefit from lowering uric acid levels.

Technical Specifications:

• CAS ID: 57-66-9
• Synonyms: 4-(Dipropylsulfamoyl)benzoic acid
• Molecular Formula: C13H19NO4S
• Molecular Weight: 285.36 g/mol
• Melting point: 195 C
• Boiling Point: 438 C
• Solubility: Nearly insoluble in water, soluble in chloroform
• pH level: 7.4
• Storage condition: Less than 40 C

How does it work:

Since decades, probenecid has been used to treat gout. The drug inhibits a renal tubular transporter, which facilitates excretion of the disease-causing uric acid by blocking reuptake.

The uricosuric drug, probenecid, inhibits the tubular reabsorption of filtered and secreted uric acid, increasing its excretion.

Applications Or where it is used:

Probenecid is prescribed to treat chronic gout and gouty arthritis. The medication prevents gout attacks, not treats them. It works by removing uric acid from the body through the kidneys.

Manufacturing process:

It consists of the following steps: heating a water bath to 75-80C to completely dissolve probenecid in ethyl alcohol; dropping a solution of sodium hydroxide, potassium hydroxide, or absolute ethyl alcohol, dissolved in advance at 70 degrees Celsius.

How to use:

It is recommended that you take this medication twice daily by mouth with food or antacids to relieve stomach upset or as your doctor directs. While taking this drug, it is best to drink a full glass of water with each dose and at least eight more glasses (8 ounces each) each day to prevent kidney stones. Consult your doctor if you are on a restricted fluid intake. Your dose will depend on your condition and response to therapy. In cases of sudden/severe gout attacks, probenecid should not be started. Instead, wait until the current attack ends before starting it. As your body removes extra uric acid, you may experience an increase in gout attacks during the next few months. While taking probenecid, continue taking your gout pain medications along with it.

Side effects:

Symptoms such as nausea, loss of appetite, dizziness, vomiting, headache, sore gums, and frequent urination may occur as your body adjusts to the medicine. The majority of people using this medication have no serious side effects. You should contact your doctor immediately if you experience any of these unlikely but serious side effects: lower back pain, difficult/painful urination, or a change in urine amount or color. An allergic reaction to this drug is rare.

Warnings and precautions while using this product:

If you have an allergy to probenecid, or if you have any other allergies, tell your doctor or pharmacist before you take it. Inactive ingredients can cause allergic reactions or other problems with this product. For more information, contact your pharmacist. 

If you have a history of cancer treatment, a specific enzyme deficiency (G6PD), kidney problems (e.g., kidney stones, obstruction), or peptic ulcer disease, tell your doctor before taking this medication. Pregnant women should take this medication only when absolutely necessary. Your doctor can advise you on the benefits and risks.